Profile

Teaching Areas

• Pharmaceutical Technology
• Physical Pharmacy
• Pharmaceutical Chemistry
• Pharmaceutical Biotechnology
• Drug delivery systems and nanotechnology
• Computer aid Drug design.

Research Interests

• Drug delivery systems (DDS), targeted drug delivery, Cell-based drug delivery, a nanotechnological approach for the development of novel drug delivery systems for anticancer drugs.
• Screening novel active pharmaceutical compounds from natural resources.
• Nanotechnological approaches for targeted drug delivery and designing novel DDS based on nanotechnology.
• Developments of new analytical methods/techniques for quality assessment and standardizations of novel drug forms and substances.
• Small heterocyclic molecules with anticancer, antimicrobial, antiviral, antiinflammation, anti-tuberculosis properties.
• Solid and liquid dosage formulations development.
• Molecular modeling, drug designed and bioinformatics.

Other

• Member of the Subject Expert Panel of Pharmacist at Ceylon Medical Collage council since 01^st August 2022.

Other responsibilities

Publications

Books

• Encapsulation of indole alkaloids into erythrocyte carriers (originally in Russian language) (Инкапсулирование терпено индольных алкалоидов в эритроцитарные носители), LAP Lambert Academic Publishing – ISBN-13: 978-620-0-00865-7 ISBN-10: 6200008655 EAN: 9786200008657 –
• Halahakoon Mudiyanselage Amila Jeewantha Halahakoon (Democratic Socialist Republic of Sri Lanka) THE OBTAINED AND STANDARDIZATION OF ENCAPSULATED ERYTHROCYTES CARRIER WITH TERPENE-INDOLES ALKALOIDS ANTICANCER DRUGS 14.04.02. – Pharmaceutical chemistry, pharmacognosy, Abstracts of Dissertations for the scientific degree of candidate of pharmaceutical sciences Moscow – 2018  https://search.rsl.ru/en/record/01008699746?ysclid=lyztai7at1856316881
• [ Original document in Russian – Халахакун Мудиянселаге Амила Дживанта Халахакун.
• Получение и стандартизация эритроцитарных носителей, инкапсулированных терпено-индольными алкалоидными противоопухолевыми препаратами: автореферат дис. … кандидата фармацевтических наук: 14.04.02 / Халахакун Мудиянселаге Амила Дживанта Халахакун; [Место защиты: Рос. ун-т дружбы народов]. – Москва, 2018. – 26 с.
• Фармацевтическая химия и фармакогнозия
• Здравоохранение. Медицинские науки — Фармакология — Противоопухолевые средства — Исследование и контроль Шифр хранения:OD 9 19-14/61]

Referred Journal articles

• Halahakoon Amila Jeewantha, Slivkin Aleksei Ivanovich, Karlov Pavel Mihailovich. Validated spectrophotometric method for the estimation of vincristine and vinblastine. Int J Pharm Pharm Sci 2017;9(4)
• Jeewantha HMA, Slivkin AI. The terpene-indole alkaloids loaded erythrocytes as a drug carrier: design and assessment. Russian Open Medical Journal 2018; 7: e0406.
• Jeewantha Halahakoon Mudiyanselage Amila. ?Systems for the delivery of chemotherapeutic drugs, new approaches and perspective? Russian Open Medical Journal, vol. 6, no. 3, 2017, pp. 302.
• Trineeva O.V., Halahakoon A.J., Slivkin A.I., Chupandina E.E. morphological and physico-chemical properties of erythrocyte carriers encapsulated by terpineindolic alkaloids. Drug development & registration. 2018;(1):146-150. (In Russ.)
• Trineeva O.V., Halahakoon A.J., Slivkin A.I. CELL CARRIERS AS SYSTEMS OF DELIVERY OF ANTITUMOR DRUGS (REVIEW). Drug development & registration. 2019;8(1):43-57. (In Russ.) https://doi.org/10.33380/2305-2066-2019-8-1-43-57
• Trineeva O.V., Halahakoon A.J. Study of Desorption and Exemption of Terpeno-indole Alkaloids of Vincristine and Vinblastine from Erythrocyte Cell Carriers. Drug development & registration. 2019;8(2):16-21. (In Russ.) https://doi.org/10.33380/2305-2066-2019-8-2-16-21
• Trineeva O.V., Halahakoon A.J., Slivkin A.I. cell carriers as systems of delivery of antitumor drugs (review). Drug development & registration. 2019;8(1):43-57. (In Russ.) https://doi.org/10.33380/2305-2066-2019-8-1-43-57
•  Trineeva O.V., Halahakoon A.J., and Slivkin A.I. ?Development and validation of methods for spectrophotometric quantitative determination of terpene-indole alkaloids (using the example of vincristine sulfate and vinblastine sulfate)? Current problems of medicine, vol. 41, no. 4, 2018, pp. 687-702. [ ???????? ?.?., ????????? ?.?., and ??????? ?.?. ??????????? ? ????????? ??????? ??????????????????????? ??????????????? ??????????? ???????-????????? ?????????? (?? ??????? ??????????? ???????? ? ??????????? ????????)? ?????????? ???????? ????????, vol. 41, no. 4, 2018, pp. 687-702.]
• Slivkina I, Kondrashina OV, Halahakoon MAJ, Belenova AS. DNA based hybrid liquid crystalline nano organometallic composites for targeted drug delivery in neutron capture therapy. Int J Pharm Pharm Sci 2017;9(6):74-79.
• Aleksandrovna, P. Y., S. A. Ivanovich, and H. A. Jeewantha. ‘Validation of assay procedures of afobazole in microcapsules’. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, no. 5, May 2017, pp. 278-81, doi:10.22159/ijpps.2017v9i5.16684.
• : Polkovnikova Y, Koryanova K, Jeewantha HA.  Quantum-chemical free energy calculation of vinpocetine molecule release from sodium alginate. Marmara Pharm J. 2018; 22 (3): 443-449. https://doi.org/10.12991/jrp.2018.85     
• O. V. Trineeva, A. I. Slivkin, A. J. Halahakoon methods of qualitative and quantitative determination of terpen-indoal alkaloids of the plant of the genus catharanthus (review), BULLETIN OF VSU, SERIES: CHEMISTRY. BIOLOGY. PHARMACY, 2019, no.4, 109-120. http://www.vestnik.vsu.ru/pdf/chembio/2019/04/2019-04-16.pdf

Conference papers

• HMAJ Halahakoon Is Discrete Incremental Meta Docking (DIMD) the Key to Success in Molecular Docking-based Drug Discovery? A comparison of the Results of the Novel Vinca Derivative VADRPA01, 17^th international research conference unravelling the paradigm shift: revolutions in the era of AI (September 26–27, 2024 )At: Rathmalana, Colombo. http://ir.kdu.ac.lk/handle/345/7986
• NRM Nelumdeniya, MGLS Dias, RDVK Kalhari,  HMAJ Halahakoon, Exploring Phytochemicals in Glycyrrhiza Glabra L. Root as Potential Therapeutics for Gastroesophageal Reflux Disease: A Molecular Docking and Dynamics Study, 17^th international research conference unravelling the paradigm shift: revolutions in the era of AI ( September 26–27, 2024 )At: Rathmalana, Colombo.  http://ir.kdu.ac.lk/handle/345/7964
• HMAJ Halahakoon, Sriaandhal Sabalingam, BSS Perera, PVCI Pramuditha, The Study of An Anti-Diabetic Activity Using Syzygium Cumini, Costus Speciosus, and Melastoma malabathricum Plant Extracts Compared to Standard Acarbose,17^th international research conference unravelling the paradigm shift: revolutions in the era of AI ( September 26–27,2024) At: Rathmalana, Colombo. http://ir.kdu.ac.lk/handle/345/8181
• HMAJ Halahakoon, N R M Nelumdeniya, SC Vithana, WH Sandaru, Enhancing the Solubility of Atorvastatin Calcium: A Comparative Study of Solid Dispersions with β-Cyclodextrin, Chitosan, and PEG-4000, 17^th  international research conference unravelling the paradigm shift: revolutions in the era of AI ( September 26–27, 2024 )At: Rathmalana, Colombo.
• HMAJ Halahakoon, SDS Perera, ,Sriaandhal Sabalingam, S Kamalanathan Formulation of Anti-inflammatory Topical Application using Acronychia pedunculata, Thespesia populnea and Madhuca longifolia Extract, 17^th  international research conference unravelling the paradigm shift: revolutions in the era of AI ( September 26–27, 2024 )At: Rathmalana, Colombo. http://ir.kdu.ac.lk/handle/345/8183
• HMAJ Halahakoon The assessment of the capping tendency of the tablet during the pharmaceutical tabletting using finite element analysis in computational modelling tools ‘General Sir John Kotelawala Defence University ’15th International Research Conference 2022.
• Halahakoon Amila Jeewantha, NRM Nelumdeniya MJJH Fernando, SC Ilangamge In-Vitro Evaluation of Gastroprotective Activity and Phytochemical Screening of the Aqueous Leaf Extract of Cyclea peltate General Sir John Kotelawala Defence University -15th International Research Conference 2022.
• HMAJ Halahakoon, In silico study of the computationally designed novel Vinca alkaloid derivatives VADRPA01 and VADRPH01 effects on Calmodulin and Calmodulin dependent Ca²⁺ transport ATPase, General Sir John Kotelawala Defence University -16th International Research Conference 2023.
• AJ Halahakoon, OV Trineeva Study of the stability and shelf life of cellular forms of terpene-indole alkaloids vincristine and vinblastine, Publication date 2018 Conference materials 'WAYS AND FORMS OF IMPROVING PHARMACEUTICAL EDUCATION. CURRENT ISSUES IN THE DEVELOPMENT AND RESEARCH OF NEW MEDICINES Pages 648-652.
• Halahakoon Mudiyanselage Amila Jeewantha Halahakoon, PLASMA AND BLOOD CORPUSCLES BINDING CHARACTERISTICS OF THETERPINE INDOLES ALKALOIDS VINCRISTINE SULFATE AND VINBLASTINSULFATE, CyberAuditorium™ Publication 20.10.2019, DOI: http://doi.org/10.13140/RG.2.2.36393.54887

Graduate supervision

• Supervision of undergraduate research projects of B Pharm students of FAHS, KDU (Since 2021)

Technical Reports 

• HMAJ Halahakoon, Phytochemical Analysis of Various Groups of Flavonoids in Medicinal Plant Materials, (ФИТОХИМИЧЕСКИЙ АНАЛИЗ РАЗЛИЧНЫХ ГРУППЫ ФЛАВОНОИДОВ В ЛЕКАРСТВЕННОМ РАСТИТЕЛЬНОМ СЫРЬЕ), AJH_AS_PF_FLV_001, Affiliation: Voronezh State University, http://doi.org/10.13140/RG.2.2.17938.61128

Awards & Grants

• Best oral presentation for Department of Pharmacy at 17^th KDU IRC 2024